General Test Procedure Identification by Solubility
- Purpose
- This procedure is applicable to all incoming Raw materials, In-process and Finished products.
- Apparatus
- Calibrated Balance.
- Reagents
- Solvent as mentioned in STP
- Procedure
- Weigh accurately a suitable quantity of sample into a glass stoppered test tube and add specified
quantity of solvent as per the table given below.
-
- Shake vigorously to dissolve, keep aside for 15 minutes.
- If sample has not been completely dissolved repeat step no. 2.
- The term miscible is used to describe a liquid that is miscible in 1:1 proportion with a stated solvent:
Sr. No
Solubility term
Volume of solvent
(in part)
Weight of sample & Quantity of solvent
Very soluble
Less than 1
5g in 5ml
Freely soluble
1 to 10
1g in 10ml
Soluble
10 to 30
0.5g in 15ml
Sparingly soluble
30 to 100
0.1g in 10ml
Slightly soluble
100 to 1000
0.05g in 50ml
Very slightly soluble
1000 to 10,000
0.01g in 100ml
Practically insoluble
More than 10,000
NA
Soluble articles, when brought into solution, may show traces of physical impurities, such as minute
-
fragments of filter paper, fibers and other particulate matter, unless limited or excluded by definite
tests or other specifications in the individual monograph.
- Reference
- IP
- Revision History
-
Revision No.
Details of Changes
Reason for change
00
New GTP
NA
End of Document
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