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General Test Procedure Identification by Solubility

 

General Test Procedure Identification by Solubility

  1. Purpose
    1. This procedure is applicable to all incoming Raw materials, In-process and Finished products.
  2. Apparatus
    1. Calibrated Balance.
  3. Reagents
    1. Solvent as mentioned in STP
  4. Procedure
    1. Weigh accurately a suitable quantity of sample into a glass stoppered test tube and add specified

                           quantity of solvent as per the table given below.

    1. Shake vigorously to dissolve, keep aside for 15 minutes.
    2. If sample has not been completely dissolved repeat step no. 2.
    3. The term miscible is used to describe a liquid that is miscible in 1:1 proportion with a stated solvent:
      Sr. No

      Solubility term

      Volume of solvent

      (in part)

      Weight of sample & Quantity of solvent

      Very soluble

      Less than 1

      5g in 5ml

      Freely soluble

      1 to 10

      1g in 10ml

      Soluble

      10 to 30

      0.5g in 15ml

      Sparingly soluble

      30 to 100

      0.1g in 10ml

      Slightly soluble

      100 to 1000

      0.05g in 50ml

      Very slightly soluble

      1000 to 10,000

      0.01g in 100ml

      Practically insoluble

      More than 10,000

      NA

      Soluble articles, when brought into solution, may show traces of physical impurities, such as minute

                               fragments of filter paper, fibers and other particulate matter, unless limited or excluded by definite

                                  tests or other specifications in the individual monograph.

  1. Reference
    1. IP
  2. Revision History

Revision No.

Details of Changes

Reason for change

00

New GTP

NA

End of Document

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