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General Test Procedure Loss on drying

General Test Procedure Loss on drying

  1. Purpose
    1. This procedure is applicable to all incoming Raw materials, In-process and Finished products.
  2. Apparatus
    1. Hot air oven/vacuum oven
    2. calibrated thermometer
    3. Calibrated Balance
  3. Reagents
    1. None
  4. Procedure
    1. Weigh a glass stoppered, shallow weighing bottle that has been dried under the same conditions to be

                        employed in the determination. Transfer to the bottle the quantity of the sample specified in the

                         individual monograph, cover it and accurately weigh the bottle and the contents. Distribute the

                          sample as evenly as practicable by gentle sidewise shaking to a depth not exceeding 10 mm. Place the

                          loaded bottle in the drying chamber (oven or desiccators) as directed in the monograph, remove the

                        stopper and leave it also in the chamber. Dry the sample to constant weight or for the specified time

                       and at the temperature indicated in the monograph. After drying is completed, open the drying

                      Chamber, close the bottle promptly and allow it to cool to room temperature (where applicable) in a

                      desiccators before weighing. Weigh the bottle and the contents.

                       

Conditions of Loss on drying:

(a) In a desiccators : The drying is carried out over phosphorus pentaoxide at atmospheric    pressure and at room temperature.

(b) In vacuum : The drying is carried out over phosphorus pentoxide at a pressure 1.5 to 2.5    kPa at room temperature.

(c) In vacuum : Within a specified temperature range: The drying is carried out phosphorus    pentoxide at a pressure of 1.5 to 2.5 kPa temperature range specified in the    monograph.

(d) In an oven : Within a specified temperature range: The drying is carried out in an Oven    within the temperature range specified in the monograph.

(e) Under high vacuum: The drying is carried out over phosphorus pentoxide at a pressure no    exceeding 0.1kPa at the temperature prescribed in the monograph.

  1. Reference
    1. IP
  2. Revision History

Revision No.

Details of Changes

Reason for change

00

New GTP

NA

 

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