Cleaning and Sanitization of Plant Premises and Equipments
1.0 Objective
To describe a procedure for general Cleaning of plant and equipments.
2.0 Scope
This procedure is applicable for general Cleaning of plant and equipments at abc company.
3.0 Responsibility
3.1 All Supervisor of HR & Administration
3.2 Manager/ Head Concern Area
4.0 Abbreviations and Definitions
SOP : Standard Operating Procedure
HR : Human Resource
CC NO : Change Control Number
cGMP : Current Good Manufacturing Practice
HOD : Head of Department
5.0 Procedure
5.1 Material Required:
5.1.1 Clean cloths
5.1.2 Liquid Soap
5.1.3 Teepol
5.1.4 Disinfectant
5.1.5 IPA
5.1.6 Mops
5.1.7 Buckets
5.1.8 Wipers
5.1.9 Vacuum cleaner
5.1.10 Toilet Brush
5.2 Method for Cleaning Change Rooms, Store, Utility, Administration, Corridors,
Staircases, Packing hall, QA & QC area :
Clean the floor free from dust with the help of dry mop before mopping the floor.
After that shall do the following activities as per table 1.
5.3 Critical area: Clean the floor free from dust with the help of vacuum cleaner
Before mopping the floor. After that shall do the following activities and record the cleaning as per annexure-I
Area | Item | Method | Cleaning & sanitizing Agent | Concentration
( % v/v) |
Frequency |
Inside Plant Premise
|
Floor | Mopping with disinfectant | Dettol | 2.5 | Twice a day |
Phenyl | 5.0 | ||||
Doors & windows | IPA mopping | IPA | 70 | Weekly | |
Glass panels | Mopping | Colin liquid | 100 | Weekly | |
Furniture & fixtures | Mopping | IPA | 70 | Weekly | |
Walls & ceiling | Mopping | IPA | 70 | Fortnightly | |
A/C grills | Mopping | IPA | 70 | Fortnightly |
Note: Disinfectant shall be used alternately to avoid the microbial resistant e.g.
Monday, Tuesday & Wednesday – Dettol 2.5%.
Thursday, Friday & Saturday – Phenyl 5.0%
5.4 Methodology of Cleaning Service floor:
The service floor shall be Cleaned everyday and remove dust with the help of Dry mop.
5.5 Methodology of Cleaning of equipments:
Each equipment which is to be used for operations to be cleaned and sanitized as per their
relevant SOP’s each equipment has the SOP for cleaning and sanitation.
5.6 Methodology of Cleaning Outside area of factory premises:
The outside area of factory premise shall be Cleaned everyday and free from dust with the help of broom.
5.7 Methodology of Cleaning of Toilet
Clean the toilet seat and floor with dilute Domex or toilet cleaner and mop the floor with 2.5 %
Dettol and 5.0% Phenyl alternatively as per below table 2 and record of cleaning as per annexure-II.
Tablet-2
Area | Item | Method | Cleaning Agent | Concentr-
ation |
Frequency | |
Premises Toilets | Toilet Seat | Cleaning | Domex /
Harpic |
10% v/v | Twice a day & on any spillage. | |
Floor |
Mopping with disinfectant | Dettol | 2.5 %v/v | Twice a day & on any spillage. | ||
Phenyl | 5.0 %v/v | |||||
Instructions:
1.0 Disinfectant shall be used alternately to avoid the microbial resistant e.g.
Monday, Tuesday & Wednesday – Dettol 2.5%
Thursday, Friday & Saturday– Phenyl 5.0%
2.0 Keep the equipments and materials used for cleaning at the place meant for the same.
3.0 Carefully Handle the Cleaning Agents.
4.0 Storage of cleaning agents and equipment: Housekeeping Room.
5.8 Following area sanitization and cleaning shall be carried out and relevant records to be maintained.
6.0 Forms and Records
6.1 Area Cleaning and Sanitization Record – Annexure-1
6.2 Toilet Cleaning Record – Annexure-2
7.0 Distribution
7.1 Master Copy – Documentation Cell (Quality Assurance)
7.2 Controlled Copy – Quality Assurance, Personnel & Administration, Production
8.0 History
Revision Number | Details For Change |
Reason for Revision |
00 | New SOP | NA |
- process validation protocol for methylcobalamin niacinamide and pyridoxine injection
validation protocol of sterility test
sop for Analytical Method Transfer
Protocol for hold time study of sterile garments
sop for swab sampling for validation of clean surfaces
cleaning validation maco and noel calculation formula
sop for performance qualification for analyst
Sop for Validation report for disinfectant efficacy
Sop for Method validation report for bacterial endotoxin test
Sop for method validation microbiology sterility testing
sop for validation report for preservative efficacy test
sop for Protocol cum report for efficacy qualification of uv light
sop for validation protocol for uv light efficacy of dpb & laf
sop for cleaning validation protocol tablet manufacturing equipment
sop for cleaning validation protocol ointment manufacturing equipmentconcurrent process validation for rabeprazole ec and domperidone sr capsules
sop for Validation for cleaning procedure liquid injection
sop for Validation for cleaning procedure dry powder injection
Preparation Approval Control and Distribution of Master Formula Records
calibration policy for equipment and instruments
evaluation Sampling of Raw Materials questionnaire
training evaluation questionnaire
sop for approval of Contract Parties
sop for Operation and Cleaning of Purified Water Generation System
sop for Storage of Standard Weights
-
process validation protocol for methylcobalamin niacinamide and pyridoxine injection
validation protocol of sterility test
sop for Analytical Method Transfer
Protocol for hold time study of sterile garments
sop for swab sampling for validation of clean surfaces
cleaning validation maco and noel calculation formula
sop for performance qualification for analyst
Sop for Validation report for disinfectant efficacy
Sop for Method validation report for bacterial endotoxin test
Sop for method validation microbiology sterility testing
sop for validation report for preservative efficacy test
sop for Protocol cum report for efficacy qualification of uv light
sop for validation protocol for uv light efficacy of dpb & laf
sop for cleaning validation protocol tablet manufacturing equipment
sop for cleaning validation protocol ointment manufacturing equipmentconcurrent process validation for rabeprazole ec and domperidone sr capsules
sop for Validation for cleaning procedure liquid injection
sop for Validation for cleaning procedure dry powder injection
Preparation Approval Control and Distribution of Master Formula Records
calibration policy for equipment and instruments
evaluation Sampling of Raw Materials questionnaire
training evaluation questionnaire
sop for approval of Contract Parties
sop for Operation and Cleaning of Purified Water Generation System
sop for Storage of Standard Weights
sop for Verification of Weighing Balance
-
Sop for Submitting of Leave Application
sop for Accident Management Procedures
sop for Accident Management Procedures
Cleaning and colour coding of Factory Apparel (Clothes)