sop for Cleaning of Water Vessel

1.0 Objective
To lay down a procedure for cleaning of water vessel.
2.0 Scope
This Standard Operating Procedure is applicable for cleaning of water vessel at abc company.
3.0 Responsibility
3.1 Operator / Manufacturing Chemist.
3.2 Head-Quality Assurance
4.0 Abbreviations and Definitions
SOP : Standard Operating Procedure
PE : Production External
QA : Quality Assurance
QC : Quality Control
SLS : Sodium Lauryl Sulphate
5.0 Procedure
5.1 Before Cleaning:
5.1.1 Ensure that all utilities are disconnected such as electricity, steam, water etc.
5.1.2 Ensure that all moving parts are properly covered.
5.1.3 Ensure that all gauges and meters, control panel, sensors, motors etc are properly covered and removable parts are removed.
5.1.4 Ensure that in sensitive places dry cleaning is done.
5.1.5 Prepare 2.5% of SLS solution 10ilter (dissolve 0.250 kg in 10 liter raw water)
5.2 Cleaning:
5.2.1 First wash all S.S. parts of the water vessel with raw water.
5.2.2 Scrap all the edges of the vessel with non particle spreading material.
5.2.3 Ensure that there is nothing except water inside the vessel.
5.2.4 Start the agitator.
5.2.5 Run for 5 minutes
5.2.6 Open the bottom valve.
5.2.7 After that open the bottom outlet valve of the water vessel and drain out the water with main drain

Pipeline of the cleaning pipeline.
5.3 First Wash
5.3.1 First wash all S.S. parts of the ointment manufacturing vessel with raw water.
5.3.2 Scrap all the edges of the vessel with non particle spreading material.
5.3.3 Ensure that there is nothing except water inside the vessel.
5.3.4 Start the agitator.
5.3.5 Run for 5 minutes.
5.3.6 Open the bottom valve.
5.3.7 Start the inline homogenizer and recalculates the water into the ointment manufacturing vessel.
5.3.8 After running the inline homogenizer for 5 minutes, stop the homogenizer and then

close the Bypass valves in the pipeline.
5.3.9 After that open the bottom outlet valve of the ointment manufacturing vessel and drain out the water

with main drain pipeline of the cleaning pipeline.
5.4 Second Wash
5.4.1 First wash all S.S. parts of the water vessel with 2.5% SLS solution.
5.4.2 Scrap all the edges of vessel with non particle spreading material.
5.4.3 Ensure that there is nothing except detergent water inside the vessel.
5.4.4 Start the agitator.
5.4.5 Run for 5 minutes.
5.4.6 After that open the bottom outlet valve of the water vessel and drain out the 2.5% SLS solution with

main drain pipeline of the cleaning pipeline..
5.5 Third Wash
5.5.1 The third wash is with DM water.
5.5.2 The procedure is to be repeated in the above sequence.
5.5.3 Send the sample to Q.C. for wash water analysis and after getting approval from Q.C. then label it as ‘CLEANED’.
6.0 Forms and Records
6.1 None
7.0 Distribution
7.1 Master Copy – Documentation Cell (Quality Assurance)
7.2 Controlled Copy – Production Department
8.0 History