sop for Cleaning and operation of labeling machine

sop for Cleaning and operation of labeling machine

1.1 To describe the cleaning & operation of labeling machine.
2.1 This procedure is applicable for labeling machine present in the production Liquid department.
3.1 Operator – To perform the procedure.
3.2 Officer production- To ensure that the operation is being performed in compliance with the

3.3 IPQA person – To ensure in-process checks, and counter check that the
Compliance is in line with SOP.

4.1 Department Head
5.1 Cleaning procedure
5.1.1 Ensure all the material is removed from the equipment.
5.1.2 Remove the product status label and affix ‘To be cleaned’ status label as per sop over the equipment.
5.1.3 Dismantle the moveable parts of machine- gum housing, label assembly and label master.
5.1.4 Dip the gum housing in 20 liter purified water for 10 minutes, then clean with nylon scrubber and mope with lint free cloth.
5.1.5 Clean label assembly and label master by moping of lint free cloth dipped in 70% IPA solution.
5.1.6 Scrub the sticky material with scrubber to remove.
5.1.7 Clean the surface of machine with lint free cloth dipped in 70% IPA solution.
5.1.8 Affix “Cleaned “Label as per sop to the machine.
5.1.9 Inform QA chemist for Line Clearance of the machine.
5.2 Operation

5.3.1 Ensure that the machine and area are cleaned before start operation.
5.3.2 Switch ON the electrical supply and release emergency button.
5.3.3 Set all change parts according to the required size.
5.3.4 Load the turn table with 4 or 5 bottles of the product to be run on line.
5.3.5 Adjust the guard line as per thickness of the bottles.
5.3.6 After ensuring smooth operation of the line, load the turn table with the filled bottles of batch to be run.
5.3.7 Push yellow button to run the machine in inching mode.
5.3.8 Push green button to run the machine.
5.3.9 Rotate the drive in clockwise direction to increase the RPM of machine.
5.3.10 Rotate the drive in anticlockwise direction to decrease the RPM of machine.
5.3.11 Push red button to stop the operation.
5.3.12 All activity to be recorded as per sop

6.1 Trainer: Department Head.
6.2 Trainee: Production, Quality Assurance and Operator person.
6.3 Period: one hour or as per required.
7.1 One set of Master copy and one set of Controlled copy submit the QA department.
8.1 NIL
9.1 QA : Quality Assurance.
9.2 IPQA : In process Quality Assurance
9.3 % : Percentage
9.4 SOP : Standard operating Procedure.
9.5 QC : Quality Control

Revision              Reason for revision Effective Date






Online Rejection in parenteral

Receipt of Batch from Production to Packing Department

sop for for Spillage Handling in parenteral area

sop for calibration of vessels with dipstick

sop for Cleaning of Bins and Containers

cip of mixing vessel and holding vessel


sop for placebo batch

sop for Cleaning of Ampoule Filling and Sealing Machine

sop for Fogging in Sterile and Non Sterile Area

sop for for Filtration of Bulk Solution

sop for fumigation in production area

sop for post cleaning after media fill

sop for cip of mixing vessel mixing mobile vessel and holding vessel

sop for De-Bagging of Three Piece Vial Dropper Caps

sop for calibration and verification of check weigher

sop for Batch number and Manufacturing and Expiry Date Coding System

sop for Sanitization of Seals

standard operating procedure machine history file

sop for operation and cleaning of Hand coder

sop for Cleaning and Handling and Silicone Tubes

sop on operation and cleaning of coating pan

sop for Operation of cleaning of pipe lines

Sop for equipment assembly

sop for operation of capsule loading machine semi automatic

sop for Machine operation capsule inspection and polishing machine

Sop for issue of material

Sop batch demarcation and batch coding

sop for material receipts

sop for monitoring of reprocessing of products

sop for in-process control on liquids orals

sop for in process controls on tablets capsules packaging line

sop for Issuance retrieval and destruction of BMR and analytical records

sop for in process controls during granulation compression coating inspection

sop for Cleaning of Blister packing machine

sop for for charge hand over between the shifts

Performance requalification report of visual inspectors

sop for Cleaning and operation of ROPP caps inspection table

sop for usage and destruction of filter pad and cartridge filter

sop for cleaning and storage of transfer pipe

sop for Cleaning and operation of labeling machine

Cleaning and operation of the mono block filling and sealing machine

sop for Cleaning and operation of empty bottle inspection table

sop for Cleaning and operation of filter press

sop for cleaning and operation of liquid transfer pump and line

sop for cleaning and operation of storage vessels

sop for cleaning and operation of sugar syrup manufacturing vessel

sop for cleaning issuance and retrieval of accessories and change parts

sop for Cleaning and operation of visual inspection conveyor belt

sop for Cleaning and operation of spray gun and assemble

sop for Fogging in Aseptic and Non Aseptic Area





Leave a Comment

error: Content is protected !!