CLEANING OF CONVENTIONAL COATING PAN
Coating pan
1. As soon as the coating operation is over, remove the coated tablets in suitable contains
Remove the dry powder from the pan, if any.
2. Pour approximately 20 liters of hot water (80-85 °C) into the pan and allow the pan to r for
about 10 minutes. Remove this turbid water using a plastic mug and transfer it into a pi bucket.
Clean the all surface of the pan with a brush having nylon teeth.
3. Place about 500 g of Sodium Hydroxide pellets into the pan and gradually put about 20 lit.
hot water (80-85 °C) into the pan, taking care that the eyes are well protected by goggle
full size PVC Gloves are worn to cover arms. Allow the pan to rotate for 10 minutes. Re this alkaline turbid water.
4. Place about 10 liters of lukewarm water (40-45 °C) into the pan. Allow the pan to rota continue
to clean the inner surface of the pan with the angular wooden brush having bristles. Remove
the water and check that the inner surface of the pan is free from any or foreign particles.
5. Place approximately 10 liters of lukewarm water (40-45 °C) into the pan and allow the rotate for 5 minutes.
Remove this water. This rinse water should be free from alkali rinsing with 10 liters of lukewarm
warm water till the rinse water is free from a indicated by a pH paper.
6 Allow the pan to rotate and wipe the inner surface of the pan with a lint free clean cloth.
Look for any scratch pits on the inner surface of the pan.
7. Cover the mouth of the coating pan with a nylon lid, affix the cleaning ticket indicating the following:
-Equipment/Machine Last Product- Batch n0 Cleaned by and ready for Product –
– Cleaned by Date- Signature
BLOWER ASSEMBLY
A. PROCEDURE FOR BATCH TO BATCH CHANGEOVER
1. Dismantling – Remove the blower pipe from the body.
2 Cleaning of blower pipe – Clean the blower pipe from inside and outside using compressed air.
Wipe the external surface with a duster.
3 Cleaning the blower body: Use a duster to wipe the outside surface.
B. PROCEDURE FOR PRODUCT TO PRODUCT CHANGEOVER
1. Dismantling – Remove the blower pipe from the body.
2 Cleaning of blower body Clean the body surface, motor and fan using compressed air from outside
as well as inside. Dedust the external surface with a duster. Wipe it with wet duster and dry it with a duster.
3. Cleaning of blower pipe – First clean it from inside and outside with a jet of potable water
using a soft nylon brush. Then clean with 0.1% Teepol solution and again with a jet of potable water.
Finally rinse with DM water.
4. Drying of the blower pipe
(a) Fix the cleaned pipe on the cleaned blower body.
(b) Start the hot air blower.
(c) Adjust the temperature of the air to 100 °C.
(d) Continue airflow till pipe gets totally dried.
(e) Switch off the heater of air blower and allow to cool to room temperature.
sop for Cleaning of Ampoule Filling and Sealing Machine
sop for Fogging in Sterile and Non Sterile Area
sop for for Filtration of Bulk Solution
sop for fumigation in production area
sop for post cleaning after media fill
sop for cip of mixing vessel mixing mobile vessel and holding vessel
sop for De-Bagging of Three Piece Vial Dropper Caps
sop for calibration and verification of check weigher
sop for Batch number and Manufacturing and Expiry Date Coding System
standard operating procedure machine history file
sop for operation and cleaning of Hand coder
sop for Cleaning and Handling and Silicone Tubes
sop on operation and cleaning of coating pan
sop for Operation of cleaning of pipe lines
sop for operation of capsule loading machine semi automatic
sop for Machine operation capsule inspection and polishing machine
Sop batch demarcation and batch coding
sop for monitoring of reprocessing of products
sop for in-process control on liquids orals
sop for in process controls on tablets capsules packaging line
sop for Issuance retrieval and destruction of BMR and analytical records
sop for in process controls during granulation compression coating inspection
sop for Cleaning of Blister packing machine
sop for for charge hand over between the shifts
Performance requalification report of visual inspectors
sop for Cleaning and operation of ROPP caps inspection table
sop for usage and destruction of filter pad and cartridge filter
sop for cleaning and storage of transfer pipe
sop for Cleaning and operation of labeling machine
Cleaning and operation of the mono block filling and sealing machine
sop for Cleaning and operation of empty bottle inspection table
sop for Cleaning and operation of filter press
sop for cleaning and operation of liquid transfer pump and line
sop for cleaning and operation of storage vessels
sop for cleaning and operation of sugar syrup manufacturing vessel
sop for cleaning issuance and retrieval of accessories and change parts
sop for Cleaning and operation of visual inspection conveyor belt
Cleaning of capsule inspection cum polishing machine
sop for cleaning of conventional coating pan