CLEANING OF DOUBLE CONE BLENDER
1.Caution :Disconnect the equipment from electrical main supply.
2. Set the position of the blender vertical-butterfly valve facing the floor
A ) PROCEDURE FOR PRODUCT TO PRODUCT CHANGEOVER
1. Dismantling-
a. Remove the safety guard of the blender
b. Remove the circular lid and gasket by unclamping wing nuts.
2.Cleaning external surfaces Clean the body of the blender with dry duster first and then with
moist duster and again wipe with a clean dry duster.
3 Position of the blender
a. Adjust the blender so that the vertical butterfly valve faces the ground.
b. Keep the butterfly valve close and keep an SS container below it.
4 Cleaning of blender:
a. Initially wash the inside surface of the blender with tap water.
b. Drain out the water through butterfly valve.
c. Clean inside surface of the blender with warm water (40 to 50 °C). Clean inside surface
of the blender with 0.1% Teepol solution.
d. Wash inside of the blender with sufficient warm water to remove the traces of Teepol.
e. Finally rinse with 5 micron filtered water.
5. Cleaning of gasket, rectangular lid and butterfly valve lid-Clean the parts with 0.1% Teepol solution.
Wash thoroughly with warm water (40-50 °C) followed by 5 micron filtered water.
6. Confirming effectiveness of cleaning The final 5 micron filtered water rinse of blender is
to be sent to Quality Control department, to confirm the absence of previous product.
7. Drying – Wipe dry, the different parts of blender using a clean lint free duster.
8. Assembling – Fix the cleaned gasket circular lid and butterfly valve and lid to the blender. +
NOTE
- Fix the ‘cleaned” label after checking cleanliness of blender duly signed by Production Officer.
2. Step 6 is a validatory exercise to be conducted once in six months at the time of product changeover.
3. If the cleaned blender is not used within 24 hours after cleaning or if there are any signs of
dust or powder settled on the outside surface then, before opening the lid, the exterior of the
blender should be wiped with wet duster followed by clean lint free duster.
B. PROCEDURE FOR BATCH TO BATCH CHANGEOVER
1.Dry clean to blender and lids with clean lint free duster.
n2. Dedust extemal surfaces with clean lint free duster.
CAUTION :Disconnect the equipment from electrical main supply.
Online Rejection in parenteral
Receipt of Batch from Production to Packing Department
sop for for Spillage Handling in parenteral area
sop for calibration of vessels with dipstick
sop for Cleaning of Bins and Containers
cip of mixing vessel and holding vessel
sop for Cleaning of Ampoule Filling and Sealing Machine
sop for Fogging in Sterile and Non Sterile Area
sop for for Filtration of Bulk Solution
sop for fumigation in production area
sop for post cleaning after media fill
sop for cip of mixing vessel mixing mobile vessel and holding vessel
sop for De-Bagging of Three Piece Vial Dropper Caps
sop for calibration and verification of check weigher
sop for Batch number and Manufacturing and Expiry Date Coding System
standard operating procedure machine history file
sop for operation and cleaning of Hand coder
sop for Cleaning and Handling and Silicone Tubes
sop on operation and cleaning of coating pan
sop for Operation of cleaning of pipe lines
sop for operation of capsule loading machine semi automatic
sop for Machine operation capsule inspection and polishing machine
Sop batch demarcation and batch coding
sop for monitoring of reprocessing of products
sop for in-process control on liquids orals
sop for in process controls on tablets capsules packaging line
sop for Issuance retrieval and destruction of BMR and analytical records
sop for in process controls during granulation compression coating inspection
sop for Cleaning of Blister packing machine
sop for for charge hand over between the shifts
Performance requalification report of visual inspectors
sop for Cleaning and operation of ROPP caps inspection table
sop for usage and destruction of filter pad and cartridge filter
sop for cleaning and storage of transfer pipe
sop for Cleaning and operation of labeling machine
Cleaning and operation of the mono block filling and sealing machine
sop for Cleaning and operation of empty bottle inspection table
sop for Cleaning and operation of filter press
sop for cleaning and operation of liquid transfer pump and line
sop for cleaning and operation of storage vessels
sop for cleaning and operation of sugar syrup manufacturing vessel
sop for cleaning issuance and retrieval of accessories and change parts
sop for Cleaning and operation of visual inspection conveyor belt
sop for Cleaning and operation of spray gun and assemble
sop for Fogging in Aseptic and Non Aseptic Area
sop for cleaning of double cone blender