Analysis method of Zinc gluconate Syrup
1.0 OBJECTIVE
1.1 To lay down a procedure for analysis of Zinc gluconate syrup.
2.0 SCOPE
2.1 This procedure is applicable to the analysis of Zinc gluconate syrup in Quality control
3.0 RESPONSIBILITY
3.1 Q.C- Chemist
4.0 ACCOUNTABILITY
4.1 Manager-Quality Assurance
5.1 Description: Pour 50 ml finish sample in beaker and observed visually.
5.2 pH: Taken 50 ml sample in beaker rinse the pH electrode first with purified water followed by sample dip the electrode in sample and observed the pH.
5.3 Volume variation: Measured the volume by measuring cylinder and determine the volume variation.
5.4 Identification:
5.4.1 In the assay, Identification by chemical method.
5.5 ASSAY:
Each 5.0ml contains
Zinc Gluconate U.S.P.
Eq. to elemental Zinc 20 mg
Estimation of Zinc gluconate:
By titration:
Dissolve about 40 mg of Zinc gluconate, accurately weight in 100 ml of water. Add 5ml of ammonia-ammonia chloride buffer and 0.1 ml of eriochrome blank (As indicator). To use and titrate with 0.005 M edetate disodium until the solution is deep in blue colour.
Each ml of 0.005 M edetate, disodium is equivalent to 2.278 mg of Zinc gluconate.
V= Volume (in ml) of Zinc Gluconate Solution consumed in titration.
N = Actual normality of Edetate Solution.
AW= Average weight
Wt. = Weight of Sample.
Calculation:
6.0 Abbreviation:
| Sr. No. | Abbreviation used | Full form of abbreviation used |
| 1.0 | STP | Standard Testing Procedure |
| 2.0 | QA | Quality assurance |
| 3.0 | STD | Standard |
| 4.0 | SPL | Sample |
| 5.0 | NM | Nano Meter |
7.0 ATTACHMENTS (ANNEXES)
NA
8.0 REFERENCE
| Sr. No. | Reference Title |
| 01 | In House |
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