Analysis of Ivermectin Suspension
1.1 To lay down a procedure for analysis of Ivermectin Suspension (VET).
2.1 This procedure is applicable to the analysis of Ivermectin Suspension (VET) in QC lab
3.1 Q.C- Chemist
4.1 Manager-Quality Assurance
5.1 Description: Pour 50ml finish sample in beaker and observed visually.
5.2 pH: Taken 50 ml sample in beaker rinse the pH electrode first with purified water followed by sample dip the electrode in sample and observed the pH.
5.3 Volume variation: Measured the volume by measuring cylinder and determine the volume variation.
5.4.1 In the assay, the principle peak in the chromatogram obtain with the test solution correspond to the peak in the chromatogram obtained obtained with the reference solution.
Each ml contains
Ivermectin I.P. 0.8 mg.
Method of Ivermectin: –
Mobile phase: METHANOL: WATER 90:10
Standard preparation: Weight accurately about 40 mg standard weight of Ivermectin diluted to 100 ml volumetric flask with mobile phase. Further dilution 10 to 50 ml with methanol.
Sample preparation: Weight accurately 10 gm sample weight diluted to 100 ml volumetric flask with
Wavelength – 245 nm
Flow rate – 1.0 ml/mint
Injection – 10 µL.
Column- C18(4.6X125mm) 5 µm.
Retention time of Ivermectin – 9.0 mint.
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|1.0||STP||Standard Testing Procedure|
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