Site icon Pharma Dekho

sop for Operation of Nitrogen and Oxygen

 

sop for Operation of Nitrogen and Oxygen

 

 

1.0 OBJECTIVE:
1.1 To lay down the Procedure for the Operation of Nitrogen and oxygen Plant.
2.0 SCOPE:
2.1 This Standard Operating Procedure shall be applicable for Operation of Nitrogen and Oxygen Plant

3.0 RESPONSIBILITY:
3.1 Operator/Technician-Engineering
4.0 ACCOUNTABILITY:
4.1 Head Engineering Department shall be responsible for compliance of SOP.

5.0 PROCEDURE:
5.1 PRIMARY CHECKS:
5.1.1 The area near the unit should be kept clean.
5.1.2 Check that all electrical system is ok.
5.1.3 Check Control panel is getting power supply.
5.1.4 Ensure that drain valves of all equipment’s  are closed.
5.2 OPERATING PROCEDURE:
5.2.1 Switch ON the main switch.
5.2.2 Turn ON the compressor and air dryer, and allow the air receiver to pressurize. Let the compressor keep

running and observe that the compressor shifts to unloaded operation.
5.2.3 Now adjust the pressure regulator placed before the inlet ball valve to required set pressure.
5.2.4 Air received in air receiver tank after filtration and pressure should be up to 5 to 7 kg/cm².
5.2.5 Air transfer into Air Separation tank A and B. A tank supply for Nitrogen Operation and B tank supply for Operation Oxygen.
5.3 OPERATING PROCEDURE FOR NITROGEN
5.2.6 Switch on Control Panel by selector switch and touch on Nitrogen icon then touch the Run icon

on display screen Open air inlet valve for Operating Nitrogen.
5.2.7 Compression, drying and filtering air transfer into Air receiver tank to PSA Modules.
5.2.8 Observe the operation of the unit for some time and see that the PSA module is working properly.

When one PSA Tower Cycle Pressurized then second PSA Tower depressurized.
5.2.9 Our PSA units have two cylinders filled with Carbon Molecular Sieve. (CMS). Compressed and

purified air flows through the cylinder; the CMS bed adsorbs oxygen, while nitrogen passes through to

the nitrogen accumulation tank. The adsorption process is interrupted before the CMS becomes saturated

with nitrogen by diverting the input air to the second cylinder, which at this point starts producing nitrogen

during this step of the cycle, the second cylinder is cleaned.
5.2.10 Check the minimum pressure in the PSA Cylinder should be 5 to 7 kg/cm².Control that air flow by

the valve provided just at the air inlet into the PSA module Setting should be disturbed only after watching the result for 5-10 minutes.
5.2.11 The pressure between the two cylinders is equalized.
5.2.12 The CMS of the first cylinder (now saturated with oxygen) is regenerated by reducing pressure in the

cylinder below that of the adsorption step. The adsorbed oxygen is released and vented into atmosphere. After

this step it is again ready for another cycle.
5.2.13 Adsorption and desorption steps are repeated in the CMS tanks at equal time intervals A constant

flow of nitrogen is stored to nitrogen surge tank and pressure has reached up to 5.5 kg/cm2,
5.2.14 At Complete Operation adsorption process Check the oxygen content in Oxygen Analyzer on control panel.
5.2.15 Check the flow rate of nitrogen via flow meter.
5.2.16 Pure nitrogen goes to Surge tank to Nitrogen Storage Tank.
5.2.17 Open Out let Valve now the plant is ready for normal operation.



5.3 OPERATING PROCEDURE FOR OXYGEN
5.3.1 Switch on Control Panel by selector switch and touch on Oxygen icon then touch the Run icon on

display screen Open air inlet valve for Operating Oxygen.
5.3.2 Compression, drying and filtering air transfer into Air receiver tank to PSA Modules.
5.3.3 Observe the operation of the unit for some time and see that the PSA module is working properly. When one

PSA Tower Cycle Pressurized then second PSA Tower depressurized.
5.3.4 Our PSA units have two cylinders filled with Carbon Molecular Sieve. (CMS). Compressed and purified

air flows through the cylinder; the CMS bed adsorbs oxygen, while nitrogen passes through to the

nitrogen accumulation tank. The adsorption process is interrupted before the CMS becomes saturated

with nitrogen by diverting the input air to the second cylinder, which at this point starts producing nitrogen

during this step of the cycle, the second cylinder is cleaned.
5.3.5 Check the minimum pressure in the PSA Cylinder should be 5 to 7 kg/cm².Control that air flow by the

valve provided just at the air inlet into the PSA module Setting should be disturbed only after watching the result for 5-10 minutes.
5.3.6 The pressure between the two cylinders is equalized.
5.3.7 The CMS of the first cylinder (now saturated with oxygen) is regenerated by reducing pressure in

the cylinder below that of the adsorption step. The adsorbed oxygen is released and vented into atmosphere.

After this step it is again ready for another cycle.
5.3.8 Adsorption and desorption steps are repeated in the CMS tanks at equal time intervals A constant flow

of nitrogen is stored to nitrogen surge tank and pressure has reached up to 5.5 kg/cm2,
5.3.9 At Complete Operation adsorption process Check the oxygen content in Oxygen Analyzer on control panel.
5.3.10 Check the flow rate of nitrogen via flow meter.
5.3.11 Pure nitrogen goes to Surge tank to Nitrogen Storage Tank.
5.3.12 Open Out let Valve now the plant is ready for normal operation.

  5.4 SHUT DOWN PROCEDURE FOR NITROGEN:



5.4.1 Touch on the Stop Icon on display screen at control panel and Switch off the control panel by Selector Switch.
5.4.2 Turn off the compressor & air dryer.
5.4.3 Switch ON the main switch.
5.4.4 Stop the air inlet supply valve and out let supply valve.
5.4.5 Maintain Log sheet as per Annexure-I.
5.5 SHUT DOWN PROCEDURE FOR OXYGEN:
5.5.1 Press the Stop Icon on display screen at control panel and Switch off the control panel Selector Switch.
5.5.2 Turn off the compressor & air dryer.
5.5.3 Switch ON the main switch.
5.5.4 Stop the air inlet supply valve and out let supply valve.
5.5.5 Maintain Log sheet as per Annexure-II

6.0 ABBREVIATIONS:

SOP Standard Operating Procedure
QA Quality Assurance
No. Number
Pvt. Private
No. Number
Ltd. Limited
EN Engineering
nm³/hr Normal Meter Cubed per Hour
kg/cm² Kilo Per Square Centi meter

 

7.0 ATTACHMENTS (ANNEXES) :
Annexure-I: Log Book of Operation Nitrogen Plant
Annexure-II: Log Book of Operation Oxygen Plant

8.0 REFERENCES:
In-House

9.0 REVISION HISTORY:

Change Control No Description New Change Effective Date Name
  New SOP Not Applicable    

                                                                                          Annexure-I:

           NITROGEN PLANT LOG BOOK    
DATE

 

 

START TIME

 

 

STOP TIME

 

AIR INLET PRESSURE kg/cm² PRESSURE OF P.S.A TOWER kg/cm² PRESSURE OF SURGE TANK kg/cm² FLOW OF N2  nm3/hr NITROGEN  % DONE BY CHECKED     BY REMARK
  Annexure-II
OXYGEN PLANT LOG BOOK
DATE

 

 

START TIME

 

 

STOP TIME

 

AIR INLET PRESSURE kg/cm² PRESSURE OF P.S.A TOWER kg/cm² PRESSURE OF SURGE TANK kg/cm² FLOW OF O2  nm3/hr OXYGEN  % DONE BY CHECKED     BY REMARK

 

 sop for Execution of Preventive Maintenance

Preparation of Sodium Hydroxide Solution

sop for Breakdown Maintenance

sop for Handling of Filters

sop for water cooled chiller operation

cleaning and preventive maintenance of LAF and RLAF

sop for replacement of water system filters

cleaning and preventive maintenance of insectocutor

sop for operation of preventive maintenance

sop for material receiving and consumption record

sop for Preventive maintenance of bottle washing machine

sop for Replacement of Battery of Electronic Devices

sop for Preparation of R.O. Antiscalant Solution

Preventive Maintenance of Rapid Cooling Steam Sterilizer

Preventive Maintenance of Rapid cooling steam Generator

sop for Preventive Maintenance of Dust Collector

sop for Replacement of HVAC filters

SOP for Battery Backup in Mobile Laminar Air Flow Trolley

sop for Replacement of Tube lights

sop for Replacement of UV light of purified water plant

sop for Cleaning of soft water storage tank and RO feed tank

sop for Preparation of Sodium hydroxide Solution

sop for Operation and regeneration of softener plant

Procedure Of Issuance Of material from Engineering Store

sop for Preventive Maintenance of Filter Press

sop for Preventive Maintenance of Sugar Transfer System

sop for Preventive Maintenance of Shrink Sleeve Machine

sop for Preventive Maintenance of ROPP Cap Elevator

sop for Preventive Maintenance of Liquid Transfer Pumps

sop for Preventive Maintenance of Liquid Tanks

Preventive Maintenance of Strip De-Foiling Machine

sop for Preventive Maintenance of Colloidal Mill

sop for Preventive Maintenance of Packing Collator Belt

sop for Checking light intensity

sop for Operation of Fire- Extinguisher

sop for Passivation of WFI Distribution Loop

sop for Analysis of Effluent Treatment Plant Water

sop for Methodology to Dispose ETP Sludge

sop for Action Plan In Case Of Electrical Power Failure

sop for Colour Coding of Piping and Accessories of Utilities

sop for Replacement Policy

sop for Disposal of Engineering Waste

Filter Cleaning of HVAC System RLAF & LAF

Procedure for Calibration of Magnehelic Gauge

Procedure for Calibration of Vacuum Gauge

Procedure for Calibration of Pressure Gauge

sop for Procedure for Calibration of Temperature Controller

sop for Area Validation

sop for Preventive Maintenance of Infrared Dryer Umbrella Type

sop for Preventive Maintenance of Battery stacker

sop for Preventive Maintenance of Lift

sop for Preventive Maintenance of Vacuum Cleaner

sop for Preventive Maintenance of laminar air flow unit

sop for Preventive Maintenance of Lozenges Manufacturing Line

sop for Preventive Maintenance of Garment Washing Machine

sop for Preventive Maintenance of Multi Column Distillation Plant

sop for Preventive Maintenance of Steam Sterilizer Autoclave

sop for Preventive Maintenance of Pure steam Generator

sop for Preventive maintenance of Depyrogenating Tunnel

sop for Preventive Maintenance of vial sealing machine

sop for preventive maintenance of Powder Filling and Rubber Stoppering machine

sop for Preventive Maintenance of Vial Washing Machine

sop for Preventive Maintenance of Inspection Table

sop for Preventive Maintenance of Hi-Cart

sop for Preventive Maintenance of Turn table

sop for Preventive Maintenance of sticker labeling machine

sop for Preventive Maintenance of Liquid Filling and Sealing Machine

sop for Preventive Maintenance of Linear Bottle Washing Machine

sop for Preventive Maintenance of De-Foiling Machine

sop for Preventive Maintenance of Strip Packing Machine

sop for Preventive Maintenance of Blister Packing Machine

sop for Preventive Maintenance of Capsule Polishing and Sorting Machine

sop for Preventive Maintenance of Capsule Filling Machine 

sop for Preventive maintenance of Auto Coater

sop for Preventive Maintenance of Compression Machine

sop for preventive maintenance of packing conveyor belt

sop for Preventive Maintenance of Sifter Cum Multi mill

sop for Preventive Maintenance of Rapid Mixer Granulator

sop for Preventive Maintenance Of Fluid Bed Dryer

sop for Preventive Maintenance of Octagonal Blender

sop for Preventive Maintenance of Lifting and Positioning Device

sop for Preventive Maintenance of Paste Preparation vessel

sop for preventive maintenance of Vibro-Sifter

sop for preventive maintenance of air curtain

sop for preventive maintenance of air handling units

Preventive Maintenance of Diesel Generator

sop for Preventive Maintenance of cooling towers

sop for Preventive Maintenance of Boiler

sop for Preventive Maintenance of Air Compressor

sop for Preventive Maintenance of Chilling Plant

sop for Preventive Maintenance of Transformers

sop for Preventive maintenance of Purified Water System

sop for Break Down maintenance of Machine and Work Requisition

sop for Building Maintenance

sop for Operation of Lift

sop for Operation of Dust Extraction System

sop for Operation Of Effluent Treatment Plant

sop for Operation Of Diesel Generator

sop for Operation of Multi Column Distillation Plant

sop for Operation of Pure Steam Generator

sop for Operation of Air Handling Unit

sop for Operation of Cooling Tower

sop for Operation of Air Compressor

sop for Operation of Water Chilling Plant

sop for Operation of Boiler

sop for Cleaning of Pure Steam Generator

Cleaning of Over Head Water Tanks HDPE

sop for Cleaning of Water tanks

sop for Sanitization of multi column plant

sop for Sanitization of Ultrafiltration System

Sop for Chemical Sanitization of Reverse Osmosis

Sop for Sanitization of Hot Sanitization & Electro Deionization unit

sop for Sanitization of Purified Water Loop

sop for preparation of sodium meta bisulphate solution

sop for Testing of Hardness of Soft Water

sop for Operation & back wash of multi grade filter

sop for testing of chlorine contents in water

 

Exit mobile version